[摘要]卵巢早衰（POF）是女性生殖系统中常见的妇科疾病，严重影响女性的生理、生育、心理健康。近年来 POF发病率呈上升趋势，且逐渐年轻化。POF的发生可能与遗传因素、自身免疫性因素、医源性因素及环境 因素有关，目前自身免疫性因素是POF临床研究的热点之一。本文围绕自身免疫性POF发病过程中的抗体、 相关因子、免疫细胞、相关信号转导通路及性激素水平与免疫变化之间的联系，对自身免疫性POF发病机制 及相关治疗机制的研究作一综述。
[Abstract] Premature ovarian failure (POF) is a common gynecological disease in the female reproductive system, which seriously affects the physiological, reproductive and psychological health of women. In recent years, the incidence of POF has shown an upward and younger trend. The occurrence of POF may be related to genetic factor, autoimmune factor, iatrogenic factor and environmental factor. At present, autoimmune factors are one of the hot spots in clinical research of POF. This review focuses on the relationship between antibodies, related factors, immune cells, signal transduction pathways, sex hormones and immune changes in the pathogenesis of autoimmune POF, and reviews the pathogenesis and treatment mechanism of autoimmune POF.