[ 摘要 ] 多囊卵巢综合征（PCOS）是育龄期女性最常见的内分泌疾病之一，患病率为 5%~10%。PCOS 可能 是一种多基因疾病，其病因较复杂，主要受到表观遗传和环境因素的影响。长链非编码 RNA（lncRNA）在 PCOS 卵泡发育等过程中发挥重要作用，在 PCOS 患者的卵泡液及颗粒细胞中均发现异常表达，其与细胞增殖和凋亡、 细胞核成熟及卵泡发育有关。本文主要综述 lncRNA 与 PCOS 患者卵子发育的关系。

[Abstract] Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, with a prevalence of 5% to 10%. PCOS may be a polygenic disease, the etiology of PCOS is complex and is mainly influenced by epigenetic and environmental factors. Long non-coding RNA (lncRNA) plays an important role in the development of follicles in PCOS. Abnormal expression of lncRNA is found in follicular fluid and granulosa cells of PCOS patients, and it is related to cell proliferation and apoptosis, nuclear maturation and follicle development. This paper mainly reviewed the relationship between lncRNA and oocyte development in patients with PCOS.

R711.6

[ 基金项目 ] 辽宁省沈阳市卫生健康委员会科研项目 （2023110）。